Invited speakerOral presentationIndustryPanel / Q&A

Wednesday 18 November

MCG, Melbourne
8:30AM - 9:00AM
Arrival & Registration
Betty Cuthbert Lounge
9:00AM - 9:15AM
Welcome
Olympic Room
9:15AM - 9:55AM
Matthew Krummel - Krummel Lab, University Of California San Francisco
Announcing Soon
Invited
9:55AM - 10:15AM
Sapna Devi - University Of Melbourne
Neural control of the tumour ecosystem in breast cancer
Invited
10:15AM - 10:30AM
Ashray Gunjur
Gut Fusobacterium animalis correlates with poor combination immune checkpoint blockade efficacy in advanced biliary tract cancer
Abstract
10:30AM - 10:45AM
Xiao Jing (XJ) Ong
An off-the-shelf KIR3DL2-directed CAR-T cells for T-cell lymphomas: Overcoming safety, manufacturing barriers and antigen escape
Abstract
10:45AM - 11:00AM
Lewis Newland
IFNɣ impedes CD8+ T cell control of metastatic melanoma in tumour-draining lymph nodes
Abstract
11:00AM - 11:30AM
Morning Tea
Betty Cuthbert Lounge
11:30AM - 12:00PM
Di Yu - University Of Queensland
Ferroptosis in T Cells: From Mechanism to Therapeutic Opportunity
Invited
12:00PM - 12:20PM
Sophia Davidson - Hudson Institute Of Medical Research
Developing novel therapeutics to regulate inflammation and cell stress in models of neurodegeneration
Invited
12:20PM - 12:40PM
Rimma Goldberg - Monash University
Engineered food antigen specific T regulatory cells are a potential cell therapy for inflammatory bowel disease
Invited
12:40PM - 1:00PM
Claudia A Nold-Petry
Repurposing Anakinra (Interleukin-1 receptor antagonist) for Early-Life Inflammatory Diseases in Extremely Preterm Infants
Abstract
1:00PM - 2:00PM
Lunch
Betty Cuthbert Lounge
2:00PM - 2:30PM
Claire Borg - Moderna
Programming the Immune System for Cancer
Industry
2:30PM - 2:50PM
Christophe CM Macri
Exploiting dendritic cell biology with next-generation mRNA-lipid nanoparticle vaccines
Abstract
2:50PM - 3:00PM
Alicia K Yong
Development of a Novel mRNA Vaccine for Alzheimer’s Disease
Abstract
3:00PM - 3:30PM
Dr Sarah Herridge & Dr Simon Hardwick - BioNTech
Accelerating Research Translation of mRNA-Based Innovation
Industry
3:30PM - 4:00PM
Afternoon Tea
Betty Cuthbert Lounge
4:00PM - 5:00PM
Laureate Professor Emeritus Peter Doherty
Announcing Soon
Panel / Q&A
5:00PM - 7:00PM
Poster Session I
Betty Cuthbert Lounge
7:00PM - 10:00PM
Conference Dinner
Olympic Room
Professor Georgina Long
Curing the third space: cancer is real, so who needs what and by when?
Melanoma Institute Australia, The University of Sydney, North Sydney, NSW, Australia
Checkpoint inhibitor immunotherapy, and now mRNA-based personalised vaccines have transformed melanoma, yet many patients are still not cured and die of their disease. Progress for these patients, the third space, is slowed not only by the time it takes to understand the biology and develop effective new therapies, but by how oncology is practised: legacy drugs that anchor trial design, endpoints that take years to mature, and a caution rooted in “first, do no harm” that can become a fear of doing worse, even where the disease offers little worse to fear. What does the field need to accelerate?

Thursday 19 November

MCG, Melbourne
9:00AM - 9:40AM
Kim Good-Jacobson - Monash Biomedicine Discovery Institute
Memory B cells and plasma cells in chronic infectious disease
Invited
9:40AM - 10:00AM
Matthew J Worley
Establishing an iPSC Derived Lung Triple Culture to Model Viral Exacerbations of COPD and Preschool Wheeze
Abstract
10:00AM - 10:30AM
Simon Phipps - QIMR Berghofer
How breast milk components influence neonatal immunity in the lung
Invited
10:30AM - 11:00AM
Morning Tea
Betty Cuthbert Lounge
11:00AM - 11:20AM
Samuel Forster - Hudson Institute Of Medical Research
Announcing Soon
Invited
11:20AM - 11:40AM
Misty Jenkins - Walter And Eliza Hall Institute Of Medical Research
Announcing Soon
Invited
11:40AM - 12:00PM
David Khoury - Kirby Institute, UNSW
Pre-clinical data in vaccine development, assessment and deployment
Invited
12:00PM - 12:30PM
Q & A Panel
With Samuel Forster, Misty Jenkins and David Khoury
Panel / Q&A
12:30PM - 2:00PM
Lunch
Betty Cuthbert Lounge
2:00PM - 2:30PM
Sherene Loi - Peter Maccallum Cancer Centre
Rethinking immune responses in breast cancer
Invited
2:30PM - 2:45PM
Louis Perriman
iPSC generated γδ T cells for the production of an ‘off-the-shelf’ cellular therapy to treat human disease.
Abstract
2:45PM - 3:00PM
Kayla R Wilson
A new immunometabolic checkpoint for CD8+ T cell immunity
Abstract
3:00PM - 3:30PM
Cameron Turtle - The University Of Sydney
Clinical trials of CD19 CAR-T cell immunotherapies
Invited
3:30PM - 4:00PM
Afternoon Tea
Betty Cuthbert Lounge
4:00PM - 4:30PM
Siok Tey - Royal Brisbane And Women’s Hospital & QIMR Berghofer
Announcing Soon
Invited
4:30PM - 5:00PM
Charles Swanton - Francis Crick Institute & UCL Cancer Institute
Announcing Soon
Invited
5:00PM - 5:10PM
Prizes & Concluding Remarks
Olympic Room

Poster List

Poster Session I · Wednesday 18 November
75 posters
#101
Mohammadreza Mohamadreza Sheikh Sheikh Sajjadieh
Membrane Dynamics Index Identifies Immune-Inflamed and Immune-Desert States in Lung Adenocarcinoma
#102
Le Hoang
Exploring STING response within dendritic cells to improve immunotherapy efficacy
#103
Georgia Dow
Investigating CD4+ and CD8+ T cell responses to a nested peptide
#104
Janin Chandra
Circulating CD5⁺ dendritic cells link gut microbiome function to immunotherapy response in cancer patients
#105
Simon Manuel ST Tria
Co-culture platform of patient derived organoids and autologous T cells to discover novel immunotherapeutic options
#106
Venkateswar Addala
Tumour antigen atlas for paediatric brain cancer vaccine development
#107
Aditya Manna
Financial Toxicity and Access Barriers to Cancer Immunotherapy in Low- and Middle-Income Countries: Perspectives from Rural Eastern India
#108
Shiyi Wu
Leveraging mRNA–LNP Technology for In Vivo CAR Immune-Cell Engineering
#109
Gabriel Goncalves
Circulating HLA Ligandomes Reflect Tumour Antigen Landscapes in Pathological Non-Responding (pNR) Melanoma Treated with Neoadjuvant Immune Checkpoint Inhibitors (ICI).
#111
Wanxiaojie Xie
Preclinical Evaluation of Cytokine-Adjuvanted Multivalent MVA Vaccines Encoding Influenza A Virus and SARS-CoV-2 Antigens
#112
Rachel Song
From Throat to Skin: Bacteria-Triggered Autoimmunity Shaped by Genetic Susceptibility
#113
Zoe Magill
The unintended effects of melanoma targeted therapies on dendritic cell-mediated immune responses
#114
Misty R Jenkins
Tumour-directed PD-L1×CD137 bispecific immunomodulation unlocks curative multi-target CAR T cell therapy in glioblastoma
#115
Misty R Jenkins
PDGFRa-CAR T cells induce sustained remission in a representative model of disseminated pediatric high-grade glioma
#116
Danielle Blud
Optimising a machine learning algorithm for immunotherapy target identification in brain cancer
#117
Ludivine Grzelak
Revealing dose and repeat effects of a novel Influenza vaccine on humoral immunity
#118
Jin Ng
Understanding the Role of γδ T Cells in Immunotherapy Responses in Small Cell Lung Cancer
#119
Milie M Desai
Exploring CAR T cell therapy and immunomodulatory agents in immunocompetent paediatric brain cancer models
#120
Vivian Tran
Integrating human and experimental models to identify immune mechanisms underlying cardiovascular complications in Long COVID.
#121
Javad Masoumi
Identification of shared immunogenic non-canonical HLA-A*02:01-presented peptides for therapeutic cancer vaccine development in BRCA-deficient breast cancer
#122
Matilda Doran
Microbiota-derived choline metabolites improve CD8+ T cell responses and correlate with ICI efficacy in melanoma patients
#123
Maleika Osman
Precision engineering of CAR-T cells for tumour-restricted secretion of cytokines in a novel syngeneic multiple myeloma model
#124
Laila Karra Khalil
A novel allogeneic Tissue Factor-targeted CAR-NK cell therapy for endometriosis
#125
Tima Shamekhi
Antigen discovery for cancer immunotherapy in paediatric diffuse midline glioma: from H3K27M neoantigens to dark antigens
#126
Anurag Adhikari
Immune Biomarkers Reveal Divergent Cellular and Humoral Responses Following Repeated Pfizer SARS-CoV-2 Booster Vaccination
#127
Keziah Ting
RNA-Seq profiling demonstrates enhanced cytotoxicity, persistence and manufacturing consistency in CTH-401, a late-preclinical-stage off-the-shelf CAR NK cell product.
#128
Sining Li
Persistent low antigen during chronic infection sustains potent CD8+ effector T cell responses that drive severe immunopathology
#129
Elham Shokati
A Single Cell Transcriptomic Atlas of CD8+ Cytokine-Induced Killer Cells from Metastatic Colorectal Cancer Patients
#130
Ashleigh S Davey
Structural tuning of CAR potency for tailored anti-CD19 CAR-T cell therapies
#131
Yoseph Adel YW Wahba Molano
A patient-derived CAM platform for rapid evaluation of glioblastoma therapies and future modelling of tumour–immune interactions
#132
Farnaz Fahimi
Development of monoallelic cell lines with non-classical HLAs
#133
Purva Trivedi
Myeloid cell-specific HCK shapes fibrotic tumour microenvironment in pancreatic cancer through macrophage-fibroblast crosstalk
#134
Hannah Walker
immune profiling reveals upregulation of profibrotic & JAK-STAT signalling as a mediator of post-HSCT lung complications in children
#135
Brittany Doran
Preclinical development of tissue factor-targeted iPSC-derived CAR-NK cells for solid tumours
#136
Ryan s Cross
Designing Novel Versatile Protease Regulatable Chimeric Antigen Receptor (VIPER) T Cell Therapies For High Grade Glioma
#137
Harry L Horsnell
Local Invasion of Melanoma Metastasis into Lymph Nodes Drives Spatially Restricted Immunosuppressive Niches Underpinned by Distinct Fibroblastic Populations
#138
Kiho Tanaka
Establishment of advanced human immune system mouse models
#139
Abhinaya Muraly
Butyrate-Driven Memory Precursor CD8⁺ T Cell Differentiation Requires Fatty Acid Synthesis
#140
Lacey Klompmaker
Treatment with recombinant IFNe induces a rapid interferon response in human endometrial epithelial organoids
#141
Jamie Tuibeo
Investigation of the immune response to HIV in a Nepalese cohort
#142
Chloe E Jackson
Microbiota-mediated epithelial crosstalk and IL-21-Stat3 signalling in γδ T Cells for improved immunotherapy in colorectal cancer
#143
Presenter announcing soon
Investigating Vδ1+ γδ T Cells in Primary Thymus and Artificial Thymic Organoids for Immunotherapeutic Applications
#144
Yannick Alexandre
The splenic fibroblastic microenvironment regulates exhausted T cell responses during chronic infection and checkpoint blockade
#145
Tina Z Zhang
Leveraging the Therapeutic Potential of Human Vδ3+ T Cells
#146
Anuratha Sakthianandeswaren
Patient Derived Tumour Organoid (PDTOs) models to advance immunotherapy approaches for Oral Squamous Cell Carcinoma (OSCC)
#147
Ryan S Cross
HSP90B1 targeting Chimeric Antigen Receptor (CAR) T cell therapy is effective in the treatment of solid tumours
#148
Zahra Taylor
Comparing therapeutic immunosuppression by the CTLA4-Ig fusion proteins abatacept and belatacept
#149
Daniel T Utzschneider
B cell lymphoma promotes regulatory T cell response to escape CD4+ T cell-mediated cytotoxicity and responses to checkpoint blockade
#150
Yuxi Cao
Follicular T cell program including CXCR5 and ICOS regulates exhausted T cell responses to chronic infection and cancer
#151
Galih GA Adhyatma
Suppressing the suppressors – new antibody strategies in cancer immunotherapy
#152
Xiaomin Wang
Structural and Functional Characterisation of LRRC15 Recognition by Therapeutic Monoclonal Antibody and Engineered Minibinders
#154
Bahar Naseri
Preclinical evaluation of a Clec9A-targeted polyhydroxybutyrate nanovaccine for cancer immunotherapy
#155
Maximilien Evrard
Spatially organised danger sensing selectively remodels intestinal tissue-resident lymphocytes
#158
Liam Neil
Employing Natural Killer Cells to Reveal Weaknesses in Breast Cancer
#159
Hugh Chalmers
Developing an ex vivo tissue platform to predict patient response to neo-adjuvant immunotherapy for triple negative breast cancer.
#160
Mark R Dowling
ctDNA-directed intervention with epcoritamab alone or in combination with lenalidomide and rituximab is feasible in the early post-CAR-T population at high risk of relapse: Interim results from EpLCART
#162
Rifqa Fayaz
Investigating changes in the absence of the cytokine negative regulator Cytokine-Inducible SH2-Containing Protein (CISH) following influenza A virus infection
#163
Yasmin M Lewis
Combination PD-1/CTLA-4 blockade diminishes the ovarian reserve, extends time to natural conception and impairs early offspring growth in mice.
#164
Mark R. Dowling
A signature of early myeloid and endothelial activation in severe ICANS derived from high-dimensional serum proteomics
#165
Cindy CA Audiger
A clinical grade type 1 dendritic cell manufacturing leveraging BATF3 expression and notch signalling
#166
Thiago Maass Steiner
Tumour microenvironments supporting close tumour–T-cell interactions and CD4⁺ T-cell cytotoxic differentiation underpin response to glofitamab in diffuse large B-cell lymphoma
#167
Pailene S Lim
Identifying multi-stage vaccine targets against Plasmodium falciparum malaria
#168
Evie Van Emmerik
Developing a Stem Cell Derived Human Alveolar Epithelial Model
#169
Jasmine JM Chuah
IFNε: A Novel Immunomodulator in High-Grade Serous Ovarian Cancer
#170
Md Jahangir Alam
Targeted depletion of CX3CR1+ immune cells attenuates joint and skin inflammation in mouse models of rheumatoid arthritis and atopic dermatitis
#171
Seyed Mohammad MJ Javadzadeh
Development of Spatial Immunopeptidomics for Tissue-Resolved Mapping of Antigen Presentation
#172
Yining Tian
Genomic Alterations in TNF-Related Cell Death Pathways as Potential Biomarkers for Personalized Therapy in Oral Squamous Cell Carcinoma
#173
Nancy Wang
B cells play an essential role in programming CD4⁺ T cell memory development following intracellular bacterial infection
#174
Anju Abraham
Mapping the Development of Protective Immunity and Relapse Risk in Plasmodium vivax Using Longitudinal Systems Immunology
#175
Lorraine A O'Reilly
Cell death therapy tailored combination with CAR T-cells or conventional treatment for late-stage head and neck cancer
#176
Shengbo Zhang
CAR-DC1: A novel next-generation dendritic cell therapy for targeting solid tumours
#177
Kellie Mouchemore
Using spatial transcriptomics and machine learning to identify biomarkers of immunotherapy response in TNBC
#178
Sanjay Sondekoppa Gopala Krishna
Computational identification and validation of cancer-specific neoantigens using CAN-IMMUNE
#179
Matthias Ernst
Inhibition of IL6 trans-signalling rewires the immune-suppressive myeloid compartment, limits liver metastases and identifies actionable colon cancer patients